Receptor Tyrosine Kinases

Figure 6-E-1.  The phosphate group of phosphotyrosine (phosphorylated tyrosine) can form several hydrogen bonds with the SH2 (Src homology 2) domain of some proteins involved in the signaling via tyrosine kinases.  

Figure 6-E-2.  Domain structure of some SH2-containing proteins.

Elegant Illustrations:

The EGF Pathway - From BioCarta.

The PDGF Pathway - From BioCarta.

Book Section:

Receptor Tyrosine Kinases and Ras - From Molecular Cell Biology by Lodish et al.

Review Articles:

Defective downregulation of receptor tyrosine kinases in cancer - EMBO J., 2004.

Grb10 and Grb14: enigmatic regulators of insulin action – and more? - Biochem. J., 2005.

Autoregulatory Mechanisms in Protein-tyrosine Kinases - J. Biol. Chem., 1998.

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development - Genes and Development, 1999.

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains - FASEB J., 2000.